ABSTRACT
Objective:To analyze the effect of different glucocorticoid administration routes in the treatment of children's secretory otitis media and impacts on immunologic function.Methods:Clinical data of children with secretory otitis media received treatment at our hospital from January 2016 to June 2016 were analyzed.Patients were divided into two groups by different glucocorticoid administration routes,Group A:intratympanic injection;Group B:oral administration.After one week,clinical effects and immunologic functions were tested and compared between the two groups.Results:A total of 87 patients were analyzed,Group A 45 cases,Group B 42 cases.After one week treatment,both of the two groups got significantly improved in audiology indexe (P<0.05),however,these index were more better in Group A when compared with those of Group B(P<0.05).Meanwhile,Group A patients got higher cure rate than that of Group B (91.1%,41/45 vs 73.8%,31/42;X2=4.558,P=0.033).Both of the two groups got significantly improved in CD3+T,CD4+T and CD4/CD8 (P<0.05) and decreased in CD8,IL-4,IFN-γ and IL-4/IFN-γ(P<0.05),but these markers changed more significant in Group A (P<0.05).Group A patients had a lower recurrence rate than Group B patients one year after treatment, the difference was statistically significant (9.76%,4/41 vs 29.03%,9/31;Log-rank X2=4.698,P=0.030).Conclusion:The treatment of children's secretory otitis media,the intratympanic injection of glucocorticoid shows a better effect than that of oral cortico-steroids.
ABSTRACT
Objective To study the effect of body fat distribution on weight-losing treatment.Methods 471 simple obesity patients were divided into two groups: visceral fat normal group and visceral fat excess group, which is according to the visceral fat measured by Inbody720 Body Compositions Analysis. An organized program with energy intake controlling and exercise for one month was taken. Body weight of all patients was measured before and after the program.Results After weight-losing treatment, the losing weight of visceral fat normal group was significantly higher than visceral fat excess group (P＜0.01), and this difference is in existence in both gender (P＜0.05 of male, P＜0.01 of female). There were no gender difference in weight-losing (P＞0.05).The higher the BMI was, the more weight-losing was. There was no age difference (P＞0.05). Conclusions The effect of weight-losing is associated with visceral fat and BMI.